Figure 2 of artcile "Sex biology in Amyotrophic Lateral Sclerosis"
Schematic illustrations of the brain areas affected in male and female ALS patients
Schematic image representative of the sex specific white matter involved in ALS. While the corpus callosum exhibits difference in both male and female brains, sex difference in atrophy of the corticospinal tract is region dependent. Atrophy of the lateral regions (precentral gyrus) is more pronounced in females while the internal capsule shows atrophy in male ALS patients. In addition, the dorsolateral prefrontal cortex and the forceps major show atrophy in female brains when compared to their control group. Images were made using Collins et al. 1999 segmentation atlas. Fill article PMID 38354985
Illustration created using Adobe photoshop, Adobe Illustrator and ITKsnap software
